DNAH8

dynein axonemal heavy chain 8

Ensembl:
ENSG00000124721
UniProt:
Q96JB1
OMIM:
603337
Synonyms:
HDHC9

Cilia effects upon perturbation of DNAH8

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.11) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
primary ciliary dyskinesia

Ciliopathy associations

  • Primary Ciliary Dyskinesia

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

D H17 and D H8, but not D H5, D H9, or D H11, colocalize with α-tubulin along the sperm axoneme, whereas the reverse picture is observed in respiratory cilia, thus explaining the phenotype restricted to sperm cells (31178125).

Model organism evidence

Mus musculus (1 reference)

Moreover, the expression levels of Dnah8 and Dnah17, two genes associated with Multiple Morphological Abnormalities of the Flagella (MMAF), were markedly reduced in the HAT group.

PMIDs: 41437299