DNAI2

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased mean corpuscular volume, enlarged uriry bladder, increased total body fat amount, decreased lean body mass, preweaning lethality, incomplete penetrance, enlarged lymph nodes

Human ciliopathy phenotype:

primary ciliary dyskinesia

Ciliopathy associations

• Primary Ciliary Dyskinesia

References: PMID:18950741

Subcellular localization

cilia, flagella

References: PMID:41410385, PMID:42010243, PMID:29113992, PMID:18950741, PMID:20709053, PMID:20707998

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Reproduction & sperm
• Cell migration & adhesion

Function

Outher dynein arm intermediate chain protein. D I and DNAI2 form a complex essential for the stability of both proteins during early stages of outer dynein arms assembly (29113992). Essential for axonemal assembly of the ODA heavy chains DNAH5 and DNAH9 (18950741). Required for ODA formation in Kupffer's Vesicle cilia and controls the stablishment of left-right doby axis and kidney formation through regulation of ciliary motility.(20709053, 20707998)