DNAI2

Cilia effects upon perturbation of DNAI2

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased mean corpuscular volume, enlarged uriry bladder, increased total body fat amount, decreased lean body mass, preweaning lethality, incomplete penetrance, enlarged lymph nodes

Human ciliopathy phenotype:

primary ciliary dyskinesia

Ciliopathy associations

• Primary Ciliary Dyskinesia

Subcellular localization

cilia, flagella

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Reproduction & sperm
• Cell migration & adhesion

Function

Outher dynein arm intermediate chain protein. D I and D I2 form a complex essential for the stability of both proteins during early stages of outer dynein arms assembly (29113992). Essential for axonemal assembly of the ODA heavy chains D H5 and D H9 (18950741). Required for ODA formation in Kupffer's Vesicle cilia and controls the stablishment of left-right doby axis and kidney formation through regulation of ciliary motility.(20709053, 20707998)

Model organism evidence