DNAI3

dynein axonemal intermediate chain 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000162643
UniProt:: Q8IWG1
OMIM:: 617968
Synonyms:: DIC3, FLJ30067, NYD-SP29, WDR63

Subcellular localization

cilia, flagella

References: PMID:41410385, PMID:42010243, PMID:9843573, PMID:24080090

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cell migration & adhesion

Function

Vertebrate orthologue of Chlamydomonas intermediate chain inner dynein arm protein IC140 which localises to Chlamydomonas flaggelar axoneme (9843573). In Chlamydomonas interacts with IC138 (WDR78 in vertebrates) and directly interacts with tubulin (24080090). Associates with inner dynein arm subunit Wdr78 in mice (30060180). Rare intragenic heterozygous in-frame WDR63 deletion identified as likely cause of occipital encephalocele in one human fetus (29285825). Similar mutations in zebrafish caused similar malformations (29285825). Also interacts with Arp2/3 to regulate actin polymerisation and inhibit cell migration, invasion, and metastasis (32128961)

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