DNAJB13

DnaJ heat shock protein family (Hsp40) member B13

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000187726
UniProt:: P59910
OMIM:: 610263
Synonyms:: RSPH16A, TSARG6

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.34) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Human ciliopathy phenotype:: primary ciliary dyskinesia

Ciliopathy associations

Primary Ciliary Dyskinesia

References: PMID:27486783

Subcellular localization

basal body, cilia, ciliary tip

References: PMID:41410385, PMID:42010243, PMID:41005307, PMID:27486783

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Protein processing & maturation

Function

Role in the proper formation and function of ciliary and flagellar axonemes in humans, preserving the integrity of the central complex of motile cilia and flagella (27486783)

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