DNAL4

dynein axonemal light chain 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000100246
UniProt:
O96015
OMIM:
610565
Synonyms:
DJ327J16, PIG27

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
tremors, preweaning lethality, incomplete penetrance, decreased exploration in new environment

Subcellular localization

basal body, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

DNAL4 localized basal body