DNALI1

dynein axonemal light intermediate chain 1

Ensembl:
ENSG00000163879
UniProt:
O14645
OMIM:
602135
Synonyms:
DJ423B22.5, HP28, P28

Cilia effects upon perturbation of DNALI1

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.85) PMID:20393562
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.22) PMID:41160700

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Light chain of axonemal inner dynein arms protein. Formation of complexes with the dynein heavy chains, actin, and caltractin/centrin molecules required in ciliary motility (9284741)

Model organism evidence

Mus musculus (1 reference)

LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects.

PMIDs: 39912490