DOCK1

dedicator of cytokinesis 1

Ensembl:
ENSG00000150760
UniProt:
Q14185
OMIM:
601403
Synonyms:
CED5, DOCK180

Cilia effects upon perturbation of DOCK1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

Ezrin, ELMO-DOCK1 and its downstream effector Rac1 cooperate and function as a module during the highly coordi ted processes of ciliary basal body targeting and docking to the apical membrane. Co-immunostainings with Cep164 confirmed that DOCK1 localised to both mother and daughter centrioles.(25516973).