DPCD

deleted in primary ciliary dyskinesia homolog (mouse)

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000166171
UniProt:
Q9BVM2
OMIM:
616467
Synonyms:
DKFZP566F084, RP11-529I10.4

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-3.94) PMID:20393562

Subcellular localization

basal body, cilia, nucleus

References: PMID:41410385, PMID:41005307, PMID:25516973, PMID:38306274, PMID:14630615

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Reported situs inversus, hydrocephalus, and suppurative rhinosinusitis in Dpcd/Poll−/− mice.