DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
- Ensembl:
- ENSG00000166171
- UniProt:
- Q9BVM2
- OMIM:
- 616467
- Synonyms:
- DKFZP566F084, RP11-529I10.4
Cilia effects upon perturbation of DPCD
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-3.94) PMID:20393562
Subcellular localization
basal body, cilia, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Reproduction & sperm
- Cell migration & adhesion
Function
Reported situs inversus, hydrocephalus, and suppurative rhinosinusitis in Dpcd/Poll鈥
Model organism evidence
Mus musculus (5 references)
Deleted in primary ciliary dyskinesia (Dpcd) is one genetic abnormality known to cause PCD, and its knockout leads to hydrocephalus in mice.
We also investigated the membrane tension of immotile cilia, which is relevant to the regulation of mechanotransduction.