DPF3

double PHD fingers 3

Ensembl:: ENSG00000205683
UniProt:: Q92784
OMIM:: 601672
Synonyms:: BAF45C, CER-D4, CERD4, FLJ14079, SMARCG3

Cilia effects upon perturbation of DPF3

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased locomotor activity, decreased prepulse inhibition, decreased grip strength, decreased bone mineral content
Mouse ciliopathy phenotype:: decreased circulating calcium level

Subcellular localization

basal body, cilia, nucleus

Functional category

Ciliary assembly/disassembly
Transcription regulation

Function

DPF3 depletion causes kinetochore fiber (K-fiber) instability, less stable kinetochore鈥搈icrotubule (KT鈥揗T) attachment and defects in chromosome alignment at the metaphase plate. DPF3 localized at the basal body of the primary cilium in quiescent vertebrate cells. Depletion of DPF3 dramatically arrested primary ciliogenesis at the initial step of axoneme extension(38661008).

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