DPYSL2

dihydropyrimidinase like 2

Ensembl:
ENSG00000092964
UniProt:
Q16555
OMIM:
602463
Synonyms:
CRMP2, DHPRP2, DRP-2, DRP2

Cilia effects upon perturbation of DPYSL2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

Neuro l protein that guides neurite growth. Also called CRMP-2, is a GSK-3尾 substrate and a microtubule- binding protein. Required for primary cilium biogenesis.