DRAM2

DNA damage regulated autophagy modulator 2

Ensembl:
ENSG00000156171
UniProt:
Q6UX65
OMIM:
613360
Synonyms:
MGC54289, PRO180, RP5-1180E21.1, TMEM77, WWFQ154

Cilia effects upon perturbation of DRAM2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.09) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal coat/hair pigmentation

Ciliopathy associations

  • Cone-Rod Dystrophy

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the DRAM2 gene cause Cone-Rod Dystrophy (PMID: 25983245).