DRC3

dynein regulatory complex subunit 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000171962
UniProt:: Q9H069
OMIM:: 618758
Synonyms:: CFAP134, DKFZP586M1120, LRRC48

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:42010243, PMID:27261005, PMID:25564608

Functional category

Ciliary assembly/disassembly
Reproduction & sperm
Cell migration & adhesion

Function

Component of N-DRC, important in flagellar motility (27261005). Studies suggest it is required for other N-DRC components to assemble into the N-DRC. Its location suggests that DRC3 could be important for transducing regulatorysig ls from the radial spokes through the base plate of the N-DRC to the dynein motor (25564608).

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