DRC5

t-complex-associated-testis-expressed 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000146221
UniProt:: Q5JU00
OMIM:: 186975
Synonyms:: D6S46, TCTE1, FAP155, MGC33600

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

flagella

References: PMID:28630322

Functional category

Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

T-Complex-Associated-Testis-Expressed 1 (TCTE1) is an evolutionarily conserved axonemal protein present from Chlamydomonas (DRC5) to mammals that localizes to the N-DRC and mouse TCTE1 is testis-enriched in its expression, with its mRNA appearing in early round spermatids and protein localized to the flagellum (28630322).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.