DRD1

dopamine receptor D1

Ensembl:
ENSG00000184845
UniProt:
P21728
OMIM:
126449
Synonyms:
D1R

Cilia effects upon perturbation of DRD1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.46) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Role in motile ciliary beating in ependymal cells by regulation of catecholamines. Mediation of cellular responses to distinct endogenous catecholamines, which suggests that primary cilia play a fundamental role in enhancing the selectivity of integrated catecholamine sig ling (23936473)

Model organism evidence

Mus musculus (1 reference)

The cilia-beating deficit observed in brain slices and in vivo is caused by elevated levels of dopamine receptors (Drd1), which are expressed in motile cilia.

PMIDs: 32060266