DRD2

dopamine receptor D2

Ensembl:
ENSG00000149295
UniProt:
P14416
OMIM:
126450
Synonyms:
D2R

Cilia effects upon perturbation of DRD2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
hypogonadism; infertility

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Reproduction & sperm
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Regulates hormone secretion and proliferation. Plays a key role in dopaminergic regulation (21673453)