DRD5

dopamine receptor D5

Ensembl:
ENSG00000169676
UniProt:
P21918
OMIM:
126453
Synonyms:
DRD1B, DRD1L2

Cilia effects upon perturbation of DRD5

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.40) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.12) PMID:41160700

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cilia length regulation

Function

Ciliary mechanosensory protein in vascular endothelial cells. DR5 activation increases cilia length in a concentration-dependent manner and restores cilia function in the mutant cells (21709211)