DROSHA

drosha ribonuclease III

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000113360
UniProt:: Q9NRR4
OMIM:: 608828
Synonyms:: ETOHI2, HSA242976, RN3, RNASE3L, RNASEN

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.62) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.5) PMID:29459680

Subcellular localization

nucleus

References: PMID:21880135

Functional category

Ciliary assembly/disassembly

Function

Knock down of GW182, hAgo2, Drosha and DGCR8 mRNA did not affect the appearance of the earliest stage of ciliogenesis but did prevent the formation and elongation of the ciliary axoneme ( 21880135).

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