DROSHA

drosha ribonuclease III

Ensembl:
ENSG00000113360
UniProt:
Q9NRR4
OMIM:
608828
Synonyms:
ETOHI2, HSA242976, RN3, RNASE3L, RNASEN

Cilia effects upon perturbation of DROSHA

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.62) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.5) PMID:29459680

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology

Function

Knock down of GW182, hAgo2, Drosha and DGCR8 mR did not affect the appearance of the earliest stage of ciliogenesis but did prevent the formation and elongation of the ciliary axoneme ( 21880135).