DVL1

Cilia effects upon perturbation of DVL1

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.53) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, flagella

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Neurogenesis & migration
• Viral interactions
• Signaling (Hedgehog, GPCRs, ion channels)
• Axon guidance & growth
• Transcription regulation

Function

Essential for the docking of basal bodies to the apical plasma membrane through the activation of the Rho GTPase. DVL and Rho are required for the pla r polarization of basal bodies that underlies directio l beating of cilia (18552847). DVL is a central component of WNT sig lling. PTEN regulates multicilia formation and cilia disassembly by controlling the phosphorylation of DVL (26399523).