DVL2

dishevelled segment polarity protein 2

Ensembl:
ENSG00000004975
UniProt:
O14641
OMIM:
602151

Cilia effects upon perturbation of DVL2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.54) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

In control mice, immunoreactivity of Dvl2 in P31 E cells was observed primarily within the BB patch with some punctate staining outside the BB patch (25043421).

Model organism evidence

Mus musculus (1 reference)

Intriguingly, we observed that the growth plate chondrocytes have randomized polarity based on the location of the primary cilia and the location of PRICKLE1, DVL2, and DVL3 localization.

PMIDs: 34423861