DVL2

dishevelled segment polarity protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000004975
UniProt:
O14641
OMIM:
602151

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.54) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

References: PMID:25043421

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

In control mice, immunoreactivity of Dvl2 in P31 E cells was observed primarily within the BB patch with some punctate staining outside the BB patch (25043421).