DVL3

dishevelled segment polarity protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000161202
UniProt:: Q92997
OMIM:: 601368
Synonyms:: KIAA0208

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

References: PMID:41005307, Human Protein Atlas

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

DVL3 (dishevelled 3) was detected at the basal body in a spatial proteomics study of primary cilia (Hansen et al., 2025, Cell, PMID 41005307), and the Human Protein Atlas also places it at the basal body.

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