DVL3
dishevelled segment polarity protein 3
- Ensembl:
- ENSG00000161202
- UniProt:
- Q92997
- OMIM:
- 601368
- Synonyms:
- KIAA0208
Cilia effects upon perturbation of DVL3
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Viral interactions
- Signaling (Hedgehog, GPCRs, ion channels)
Function
TTBK2 has the potential to effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a ki se activity-dependent manner (25297623).
Model organism evidence
Mus musculus (2 references)
SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation.
Intriguingly, we observed that the growth plate chondrocytes have randomized polarity based on the location of the primary cilia and the location of PRICKLE1, DVL2, and DVL3 localization.