DYNC1I2

dynein cytoplasmic 1 intermediate chain 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000292102
UniProt:
Q13409
OMIM:
603331
Synonyms:
DIC74, DNCI2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.99) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased circulating cholesterol level, increased leukocyte cell number, increased lean body mass, increased bone mineral content, decreased circulating hdl cholesterol level, decreased total body fat amount

Subcellular localization

basal body, centrosome, cytosol, flagella

References: PMID:25613900

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

DYNC1I2 has localized in basal body,flagella.