DYNC1LI1
dynein cytoplasmic 1 light intermediate chain 1
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000144635
- UniProt:
- Q9Y6G9
- OMIM:
- 615890
- Synonyms:
- DNCLI1
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.53) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- mydriasis, enlarged lymph nodes, enlarged prostate gland, small heart, abnormal semil vesicle morphology, increased red blood cell distribution width, abnormal lung morphology, abnormal skin morphology, preweaning lethality, incomplete penetrance, hypoplasia
Subcellular localization
basal body, centrosome
References: PMID:25613900, PMID:20026645
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Viral interactions
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Expression of a DLIC-1-binding truncation mutant of FIP3 disrupts the ability of ERC proteins to accumulate pericentrosomally (expression of a DLIC-1-binding truncation mutant of FIP3 disrupts the ability of ERC proteins to accumulate pericentrosomally.).