DYNC1LI2

dynein cytoplasmic 1 light intermediate chain 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000135720
UniProt:: O43237
OMIM:: 611406
Synonyms:: DNCLI2

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.36) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal vocalization, abnormal coat/hair pigmentation, hyperactivity, abnormal coat/ hair morphology

Subcellular localization

centrosome, cytosol, flagella

References: PMID:25613900

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

DYNC1LI2 has localized in flagella.

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