DYNC1LI2

dynein cytoplasmic 1 light intermediate chain 2

Ensembl:
ENSG00000135720
UniProt:
O43237
OMIM:
611406
Synonyms:
DNCLI2

Cilia effects upon perturbation of DYNC1LI2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.36) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal vocalization, abnormal coat/hair pigmentation, hyperactivity, abnormal coat/ hair morphology
Mouse ciliopathy phenotype:
male infertility

Subcellular localization

centrosome, cytosol, flagella

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

DYNC1LI2 has localized in flagella.

Model organism evidence

C. elegans (1 reference)

Our results suggest that the DLIC protein XBX-1 functions together with the CHE-3 dynein in retrograde IFT, downstream of the complex A proteins.

PMIDs: 12802075