DYNLL2

dynein light chain LC8-type 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000264364
UniProt:
Q96FJ2
OMIM:
608942
Synonyms:
DLC2, DNCL1B, MGC17810, RSPH22

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased locomotor activity, decreased startle reflex

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus

References: PMID:25294941, PMID:30649997

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Protein existing within cytoplasmic dynein 2. Interacts with DYNLL1 and WDR34 to control retrograde intraflagellar transport. Studies suggest that DYNLL2 may be able to function in place of DYNLL1. (25294941, 30649997)