DYNLT1

dynein light chain Tctex-type 1

Ensembl:
ENSG00000146425
UniProt:
P63172
OMIM:
601554
Synonyms:
TCTEL1, TCTEX-1, TCTEX1

Cilia effects upon perturbation of DYNLT1

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.42) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-3.05) PMID:29459680

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cilia length regulation

Function

Also known as TCTEX1. Light chain subunit of cytoplasmic dynein. Regulation of ciliary resorption and S-phase entry. Tctex-1 is not required for ciliogenesis, but is critical for cilium disassembly (21394082). Component of dynein-2. Modulator of cilia length control, depletion is associated to increased cilia length (21700358). Depletion of Tctex-1 results in increase cilia length.

Model organism evidence

Mus musculus (1 reference)

TCTEX1D2 is essential for sperm flagellum formation in mice.

PMIDs: 39827215