DYNLT3

dynein light chain Tctex-type 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000165169
OMIM:: 300302
Synonyms:: TCTE1L, TCTEX1L

Subcellular localization

cilia

References: PMID:29742051

Functional category

Motors (dynein/kinesin)
Ciliary assembly/disassembly

Function

WDR60 forms a dynein-2 subcomplex through interaction with a light-chain dimer composed of TCTEX1D2 and either DYNLT1 or DYNLT3. This interaction depends on a highly conserved 50-amino-acid region of WDR60 (residues 473–522) and is important for proper assembly of the dynein-2 complex and efficient ciliary retrograde trafficking. Disruption of the WDR60–TCTEX1D2–DYNLT1/DYNLT3 interaction or loss of TCTEX1D2 moderately impairs retrograde transport within cilia(29742051).

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