DYRK1A

dual specificity tyrosine phosphorylation regulated kinase 1A

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000157540
UniProt:
Q13627
OMIM:
600855
Synonyms:
DYRK, DYRK1, MNBH

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=23, lfc=-1.97) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
DYRK1A-related intellectual disability syndrome; Intellectual disability; Rare genetic intellectual disability with developmental anomaly

Subcellular localization

basal body, cilia, nucleus

References: PMID:32467234

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos(32467234).