DYRK1A

dual specificity tyrosine phosphorylation regulated kinase 1A

Ensembl:
ENSG00000157540
UniProt:
Q13627
OMIM:
600855
Synonyms:
DYRK, DYRK1, MNBH

Cilia effects upon perturbation of DYRK1A

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=23, lfc=-1.97) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
DYRK1A-related intellectual disability syndrome; Intellectual disability; Rare genetic intellectual disability with developmental anomaly

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos(32467234).

Model organism evidence

Xenopus (3 references)

CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis.

Correction: The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos.

PMIDs: 34787650, 33288503, 32467234