DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000127334
- UniProt:
- Q92630
- OMIM:
- 603496
Cilia effects upon perturbation of DYRK2
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- no effect
Ciliogenesis screen results (4 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.92) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=363, lfc=-3.47) PMID:30270045
Phenotypes
- Mouse phenotype:
- decreased large unstained cell number
Ciliopathy associations
- Skeletal Ciliopathy
References: PMID:34582081, PMID:32758357, PMID:39001875, PMID:40777246
Subcellular localization
basal body, nucleus
References: PMID:34259627, PMID:28242748
Functional category
- Ciliary assembly/disassembly
Function
CEP78 interacts with the EDD1-DYRK2-DDB1VPRBP E3 ubiquitin ligase complex, which is involved in CP110 ubiquitination and degradation, and identified a novel interaction between CEP78 and CEP350 that is weakened by the CEP78L150S mutation(34259627). Cep78 controls centrosome homeostasis by inhibiting EDD‐DYRK2‐DDB1Vpr BP (28242748)