DYRK2

dual specificity tyrosine phosphorylation regulated kinase 2

Ensembl:
ENSG00000127334
UniProt:
Q92630
OMIM:
603496

Cilia effects upon perturbation of DYRK2

Loss-of-function effect:
Longer cilia
Overexpression effect:
no effect

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=363, lfc=-3.47) PMID:30270045

Phenotypes

Mouse phenotype:
decreased large unstained cell number

Ciliopathy associations

  • Skeletal Ciliopathy

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

CEP78 interacts with the EDD1-DYRK2-DDB1VPRBP E3 ubiquitin ligase complex, which is involved in CP110 ubiquiti tion and degradation, and identified a novel interaction between CEP78 and CEP350 that is weakened by the CEP78L150S mutation(34259627). Cep78 controls centrosome homeostasis by inhibiting EDD鈥怐YRK2鈥怐DB1Vpr BP (28242748)

Model organism evidence

Mus musculus (2 references)

Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development.

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.

PMIDs: 39001875, 32758357