DZANK1

double zinc ribbon and ankyrin repeat domains 1

Ensembl:: ENSG00000089091
UniProt:: Q9NVP4
OMIM:: 620905
Synonyms:: ANKRD64, BA189K21.8, C20ORF12, C20ORF84, DJ568F9.2

Cilia effects upon perturbation of DZANK1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.73) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.26) PMID:41160700

Phenotypes

Mouse phenotype:: increased vertical activity
Mouse ciliopathy phenotype:: eye hemorrhage

Subcellular localization

basal body, transition zone

Functional category

Ciliary assembly/disassembly
Protein processing & maturation
Signaling (Hedgehog, GPCRs, ion channels)
Transition zone

Function

Interaction partner of NINL. NINL-DZANK1 is involved in the proper assembly and folding of the cytoplasmic dynein 1 motor complex, which is essential for intracellular dynein-based transport (26485514)

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