E2F4

E2F transcription factor 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000205250
UniProt:: Q16254
OMIM:: 600659
Synonyms:: E2F-4

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.21) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=-1.33) PMID:37771269
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Mucociliary Clearance Disorder

References: PMID:24934224

Subcellular localization

basal body, nucleus

References: PMID:28675157

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

Mediation of the transcriptional responses of Multicilin. Forms apical cytoplasmic organizing centres for multiciliogenesis, recruitment and accumulation of early regulators of centriole biogenesis to allow assembly and nucleation of deuterosomes (28675157).

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