E2F4

E2F transcription factor 4

Ensembl:
ENSG00000205250
UniProt:
Q16254
OMIM:
600659
Synonyms:
E2F-4

Cilia effects upon perturbation of E2F4

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.21) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Candidate (Z2MCilia=-1.33) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Mucociliary Clearance Disorder

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Mediation of the transcriptio l responses of Multicilin. Forms apical cytoplasmic organizing centres for multiciliogenesis, recruitment and accumulation of early regulators of centriole biogenesis to allow assembly and nucleation of deuterosomes (28675157).

Model organism evidence

Mus musculus (3 references)

Zmynd10 drives centriole biogenesis and multiciliogenesis through the transcriptional regulation of E2f4.

Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation.

PMIDs: 41413096, 39662468, 32735790

Danio rerio (1 reference)

Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates.

PMIDs: 32735790

Xenopus (1 reference)

Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates.

PMIDs: 32735790