E2F5

E2F transcription factor 5

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000133740
UniProt:: Q15329
OMIM:: 600967

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Mucociliary Clearance Disorder

References: PMID:24934224

Subcellular localization

nucleus

References: PMID:30218642

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

Both E2f4 and E2f5 contribute to multiciliated cell (MCC) formation in zebrafish. The master regulator for MCC development, Gmnc, interacts with both E2f4 and E2f5 ( 30218642).

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