E2F5

E2F transcription factor 5

Ensembl:
ENSG00000133740
UniProt:
Q15329
OMIM:
600967

Cilia effects upon perturbation of E2F5

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Mucociliary Clearance Disorder

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Both E2f4 and E2f5 contribute to multiciliated cell (MCC) formation in zebrafish. The master regulator for MCC development, Gmnc, interacts with both E2f4 and E2f5 ( 30218642).

Model organism evidence

Danio rerio (2 references)

E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish.

Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo.

PMIDs: 32196499, 30218642

Mus musculus (2 references)

Moreover, GMNC and MCI associate differentially with the cell-cycle regulators E2F4 and E2F5, which enables them to activate distinct sets of target genes (ciliary transcription factor genes versus basal body amplification genes).

Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo.

PMIDs: 30877126, 30218642

Xenopus (1 reference)

Moreover, GMNC and MCI associate differentially with the cell-cycle regulators E2F4 and E2F5, which enables them to activate distinct sets of target genes (ciliary transcription factor genes versus basal body amplification genes).

PMIDs: 30877126