EEF2

eukaryotic translation elongation factor 2

Ensembl:
ENSG00000167658
UniProt:
P13639
OMIM:
130610
Synonyms:
EEF-2, EF2

Cilia effects upon perturbation of EEF2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.86) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
spinocerebellar ataxia type 26

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Viral interactions

Function

Multiple components of translation machinery are present in the cilia of RG, including ribosome components, RPS23 and RPL19, and translation factors, EIF3C, EEF2 and EEF0G.