EFCAB5

EF-hand calcium binding domain 5

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000176927
Synonyms:: FLJ46247

Phenotypes

Mouse phenotype:: enlarged testis, abnormal testis morphology

Subcellular localization

flagella, Nuclear bodies, Mitochondria

References: PMID:39743588

Function

A sperm flagella-specific calcium-binding protein, not present in somatic motile cilia, likely involved in flagellar regulation(39743588). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella (Leung et al., 2025, Nature, PMID 39743588).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.