EFCAB6

EF-hand calcium binding domain 6

Ensembl:
ENSG00000186976
UniProt:
Q5THR3
OMIM:
619664
Synonyms:
DJ185D5.1, DJBP, FLJ23588, HSCBCIP1, KIAA1672

Cilia effects upon perturbation of EFCAB6

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.45) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased grip strength

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Positive staining for motile ciliated cells was observed in the mouse brain, however, ISH staining of ependymal cells lining the choroid plexus in the chickens was only observed in the cases of EFCAB6, FAM183A and MYCBPAP (32616903).