EFNB2

ephrin B2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000125266
UniProt:
P52799
OMIM:
600527
Synonyms:
EPLG5, HTK-L, HTKL, LERK5, MGC126226, MGC126227, MGC126228

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.29) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:40623838

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Axon guidance & growth

Function

EFNB1, EFNB2, and EPHA4 proteins colocalize or partially colocalize with Arl13b (PMID: 40623838).