EGF

epidermal growth factor

Ensembl:
ENSG00000138798
UniProt:
P01133
OMIM:
131530

Cilia effects upon perturbation of EGF

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Epidermal growth factor receptor (EGFR) ki se suppresses ciliogenesis by directly phosphorylating the deubiquiti se USP8 on Tyr-717 and Tyr-810 in RPE1 cells ( 29472535).