EGFR
epidermal growth factor receptor
- Ensembl:
- ENSG00000146648
- UniProt:
- P00533
- OMIM:
- 131550
- Synonyms:
- ERBB, ERBB1, ERRP
Cilia effects upon perturbation of EGFR
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.00) PMID:41160700
Phenotypes
- Mouse phenotype:
- decreased leukocyte cell number
Subcellular localization
basal body, cilia, endosome, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Neurogenesis & migration
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
Suppression of ciliogenesis by directly phosphorylating the deubiquiti se USP8, which stabilises the trichoplein-Aurora A pathway (29472535) and through the MEK and ERK pathway (31430961). Contributes to cell cycle progression through inhibition of ciliogenesis (29472535).
Model organism evidence
Mus musculus (1 reference)
Primary cilia promote resistance to EGFR tyrosine kinase inhibitor, osimertinib, in non-small cell lung cancer.
PMIDs: 41846983