EGFR

epidermal growth factor receptor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000146648
UniProt:
P00533
OMIM:
131550
Synonyms:
ERBB, ERBB1, ERRP

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.00) PMID:41160700

Phenotypes

Mouse phenotype:
decreased leukocyte cell number

Subcellular localization

basal body, cilia, endosome, nucleus

References: PMID:41005307, PMID:29472535

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Suppression of ciliogenesis by directly phosphorylating the deubiquiti se USP8, which stabilises the trichoplein-Aurora A pathway (29472535) and through the MEK and ERK pathway (31430961). Contributes to cell cycle progression through inhibition of ciliogenesis (29472535).