EHD3

EH domain containing 3

Ensembl:
ENSG00000013016
UniProt:
Q9NZN3
OMIM:
605891
Synonyms:
PAST3

Cilia effects upon perturbation of EHD3

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Transition zone

Function

Function in early ciliogenesis by causing mother centriole reorganisation. Regulation of membrane tubulation required for ciliary vesicle formation from smaller distal appendage vesicles. EHD1 and EHD3 bind to the Rab8 effector MICAL-L1 and affect membrane tubulo-vesicle formation and scission (25686250).