EIF3C

eukaryotic translation initiation factor 3 subunit C

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000184110
UniProt:: Q99613
OMIM:: 603916
Synonyms:: EIF3-P110, EIF3S8

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.46) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

cilia, cytosol

References: PMID:42105234

Functional category

Ciliary assembly/disassembly

Function

EIF3C may regulate the local translation of Hh pathway components in the cilium, thereby modulating Hh signaling on-site. Immunostaining confirms ribosome components and translation factors in primary cilia of embryonic radial glia (RPS23, RPL19, EIF3C, EEF2, EEF1G; RPL23A at the ciliary base) and in NIH3T3 cilia (RPS3, RPL11, RPL10A) (Liu et al., 2026, Cell Rep, PMID 42105234).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.