EIF4A3

eukaryotic translation initiation factor 4A3

Ensembl:
ENSG00000291508, ENSG00000141543
UniProt:
P38919
OMIM:
608546
Synonyms:
DDX48, EIF4AIII, FAL1, KIAA0111

Cilia effects upon perturbation of EIF4A3

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-21.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Exon junction complexes (EJCs) protein eIF4A3 and Y14 depletion impairs both centrosome organization and ciliogenesis(33649372)