EIF4E

eukaryotic translation initiation factor 4E

Ensembl:
ENSG00000151247
UniProt:
P06730
OMIM:
133440
Synonyms:
EIF4E1, EIF4EL1, EIF4F

Cilia effects upon perturbation of EIF4E

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.21) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.01, ciliated=53.0%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.82) PMID:41160700

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

cilia, cytosol, p-body

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Transcription regulation

Function

Ependymal multicilia contain ribosomes, eIFs, and R (34848703).