EIF4G1

eukaryotic translation initiation factor 4 gamma 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000114867
UniProt:
Q04637
OMIM:
600495
Synonyms:
EIF4F, EIF4G, P220, PARK18

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.30, ciliated=55.2%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.67) PMID:41160700

Phenotypes

Mouse phenotype:
increased fasting circulating glucose level, increased total body fat amount, decreased spleen weight, increased total reti thickness, decreased lean body mass, preweaning lethality, complete penetrance, decreased bone mineral density, abnormal vocalization

Subcellular localization

cilia, cytosol, microtubules, ribosome

References: PMID:34848703

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Eif3m and Eif4g were distributed as puncta close to axonemal outer MT doublets . Ependymal multicilia contain ribosomes, eIFs, and R (34848703).