ELMO1

Cilia effects upon perturbation of ELMO1

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased grip strength, decreased fasting circulating glucose level, increased leukocyte cell number, increased mean corpuscular hemoglobin, increased red blood cell distribution width, increased lean body mass

Subcellular localization

basal body, cytosol

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Ezrin, ELMO-DOCK1 and its downstream effector Rac1 cooperate and function as a module during the highly coordi ted processes of ciliary basal body targeting and docking to the apical membrane. Co-immunostainings with Cep164 confirmed that DOCK1 localised to both mother and daughter centrioles.(25516973). loss of WDR-31 together with RP-2 and ELMD-1 (the sole ortholog ELMOD1-3) results in ciliary accumulations of IFT Complex B components and KIF17 kinesin, with fewer IFT/BBSome particles traveling along cilia in both anterograde and retrograde directions, suggesting that the IFT/BBSome entry into the cilia and exit from the cilia are impacted , WDR31-RP-2-ELMD-1 as IFT and BBSome trafficking regulators(37208194).