EML4

EMAP like 4

Ensembl:
ENSG00000143924
UniProt:
Q9HC35
OMIM:
607442
Synonyms:
C2ORF2, ELP120, ROPP120

Cilia effects upon perturbation of EML4

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.57) PMID:41160700

Phenotypes

Mouse phenotype:
prolonged pr interval, preweaning lethality, incomplete penetrance, abnormal coat/hair pigmentation, abnormal vocalization

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

EML4 has localized in basal body.