ENKUR

Cilia effects upon perturbation of ENKUR

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-6.09) PMID:41160700

Phenotypes

Mouse phenotype:

increased circulating alkaline phosphatase level, no spontaneous movement, abnormal skin morphology, hemorrhage

Mouse ciliopathy phenotype:

abnormal head shape, abnormal facial morphology, male infertility

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Reproduction & sperm
• Cell migration & adhesion

Function

Required for patterning the left/right axis in vertebrates. Mutations in humans cause situs inversus (29257953). Potential role as a Ca2+ sensor that participates in the regulation of mammalian flagellar bending (29733335, 15385169).