ENO4

enolase 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000188316
UniProt:: A6NNW6
OMIM:: 131375
Synonyms:: AC023283.3, C10ORF134

Cilia effects upon perturbation of ENO4

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.72) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, cytosol, vesicles

References: PMID:41410385, PMID:42010243, PMID:31735554, PMID:32248064

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Comparison of the expression levels of ciliary implicated genes between negative and transfected cells demonstrated a significantly reduction of ENO4 (p < 0.001, by two-sided unpaired t-test)(PMID: 31735554).HOATZ mediates the maturation of the glycolytic enzyme ENO4, thus contributing to the translocation of the latter during motile ciliogenesis and flagellar genesis (PMID: 32248064).ENO4 has located to motile cilia.

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