EPB41L3

erythrocyte membrane protein band 4.1 like 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000082397
UniProt:
Q9Y2J2
OMIM:
605331
Synonyms:
4.1B, DAL1, KIAA0987

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

References: PMID:41005307, doi:10.1101/2025.05.11.653368

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

EPB41L3 has localized in basal body. Detected in primary cilia of human hypothalamic neurons by proximity proteomics (Macarelli et al., 2025, bioRxiv, doi 10.1101/2025.05.11.653368).