EPHA2

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.74) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.68, ciliated=58.2%) PMID:26595381

Phenotypes

Mouse phenotype:

abnormal lymph node morphology, enlarged lymph nodes, developmental dysplasia

Human ciliopathy phenotype:

Total congenital cataract; Posterior polar cataract; early-onset non-syndromic cataract

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Viral interactions
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

EphA2 showed stronger staining on the apical membrane of both the ciliated cells and the secretory cells as well as the cilia (30176889).