EPHA2

EPH receptor A2

Ensembl:
ENSG00000142627
UniProt:
P29317
OMIM:
176946
Synonyms:
ECK

Cilia effects upon perturbation of EPHA2

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.74) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.68, ciliated=58.2%) PMID:26595381

Phenotypes

Mouse phenotype:
abnormal lymph node morphology, enlarged lymph nodes, developmental dysplasia
Human ciliopathy phenotype:
Total congenital cataract; Posterior polar cataract; early-onset non-syndromic cataract

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

EphA2 showed stronger staining on the apical membrane of both the ciliated cells and the secretory cells as well as the cilia (30176889).

Model organism evidence

Mus musculus (3 references)

Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

PMIDs: 40397771, 38187761, 34119713

Xenopus (1 reference)

Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture.

PMIDs: 34119713