EPHA6

EPH receptor A6

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000080224
UniProt:
Q9UF33
OMIM:
600066
Synonyms:
FLJ35246

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=22, lfc=-2.04) PMID:30270045

Phenotypes

Mouse phenotype:
abnormal epididymis morphology, enlarged liver, abnormal skin morphology, abnormal spleen morphology, enlarged epididymis

Subcellular localization

flagella, lysosomes, nucleus

References: PMID:25613900

Functional category

  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

EPHA6 has localized in flagella.