EPHA6

EPH receptor A6

Ensembl:
ENSG00000080224
UniProt:
Q9UF33
OMIM:
600066
Synonyms:
FLJ35246

Cilia effects upon perturbation of EPHA6

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=22, lfc=-2.04) PMID:30270045

Phenotypes

Mouse phenotype:
abnormal epididymis morphology, enlarged liver, abnormal skin morphology, abnormal spleen morphology, enlarged epididymis
Mouse ciliopathy phenotype:
abnormal liver morphology, abnormal kidney morphology

Subcellular localization

flagella, lysosomes, nucleus

Functional category

  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

EPHA6 has localized in flagella.

Model organism evidence

Mus musculus (2 references)

Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

PMIDs: 40397771, 38187761