EPHB2

EPH receptor B2

Ensembl:
ENSG00000133216
UniProt:
P29323
OMIM:
600997
Synonyms:
DRT, EPHT3, ERK, HEK5, TYRO5

Cilia effects upon perturbation of EPHB2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged spleen, increased exploration in new environment, small spleen
Mouse ciliopathy phenotype:
abnormal reti morphology

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

Most neuronal cilia were enriched with EphA4, Efnb1, and Efnb2, with a lesser extent for Ephb2(PMID: 40623838).

Model organism evidence

Mus musculus (2 references)

Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

PMIDs: 40397771, 38187761